This is something I have literally had multiple dreams of since I was a child and has brought me out of Lego retirement. I have faith that because of the Price to Piece ratios on some of these, we will be getting regular System sets in the first wave. I have a deeply internalized bias, yet I cannot see this theme doing very, very well.
However, I'm really hoping that the $100 set of the first wave will be Bowser's Castle and not Peach's Castle. I think that Peach's Castle deserves a D2C Disney Castle-style treatment. In fact, I've been plotting out an idea for what it could look like. The only problem is that I have no experience making a large-scale MOC. I really wish that I could just send the blueprint to Lego and have that be made into the official thing! I'd love to talk some more about it, but I'm not sure if this is the right place. (I'd love to know where)
The design lead Jonathan Bennink has stated that his favorite entry in the series is Mario 64, which gives me a sigh of relief. It is my favorite as well, so I hope a lot of sets cater toward that game's interpretation of things
The really interesting thing is that I actually think there is a lot of similarity between the process of making a Lego set, where all these different isolated scenes are physically plotted out into one location in a way that makes sense (Temple of the Crystal Skull is a great example of this) and the very similar way levels are designed in 64, Sunshine, and Odyssey, where all the different parts of a level must be put together in a way that flows well with all of it.