Once you open a MISB set, it's value decreases so much, that you would regret opening it later. I always buy lego sets and say "I want to keep this in the package, so in years to come, I'll make big bucks", but I cannot resist the temptaion. I will only keep a set MISB if it is old, or discountinued. (And if I only have one of them. If I bought 50 in bulk, I would open one or two, and keep the rest sealed)
I don't know if this was mentioned earlier, but check this out X-O X-O X-O
Check ALL his pirate things.
http://www.bricklink.com/store.asp?p=BrickBuy&itemID=8547455
YIKES! Lucky, lucky, lucky....