No it doesn't
If you were to have a little overhang, then it's no issue at all.
But too much overhang would enhance the vig size too much and thus vioulate the rule of building on a 16x16, 32x32 or 48x48 baseplate.
It all depends on what exactly you're doing.
A few studs of branches or stuff like that wont piss me off, if that's what you're asking?