Well the idea with MLCAD for a large model is, much like official large lego model instructions, that one builds the MOC in pieces or modules.
You build a part then save it as a model file, where it becomes essentially one large piece.
This I believe also cuts down on rending as it no longer renders each individual part of the model.
But regardless of whether that is true or not you are, until the very end where you assemble the modules, working with much smaller part counts.
SR3D Builder might be great for all I know. But I won't touch anything that isn't MLCAD. I can't work without the four view panes in CAD software. Placing parts in a 3d only viewing environment is just not feasible.