First the creations. I think the Apocalypse is awesome. The little devastator is neat, too. But the best is the dragon - I love organic creations.
Okay, I voted for option number 1. I can just see Piranha or someone pulling a Brotherhood member out of the ruble of the explosion, Piranha about to ask about the main character, and then the meber just shakes his head. And then a memorial scene.