My guess is a soft remake of 76037, if Rhino is a mechsuit again and not a large man. Probably more emphasis on Rhino than Sandman this time, given Lego's unhealthy obsession with making mechs.
On new possible prints and molds:
Electro- will need a new face print. No existing ones really look like Jamie Foxx. Also a new torso print for the high vis jacket.
Goblin- I doubt he'll have arm printing. I can see torso and leg printing, and maybe a new helmet/hood thing? I doubt new face printing, remember Killmonger and Homecoming Vulture.
Doc Ock- it seems obvious that he'll get a new face, torso and leg print, and the trenchcoat will annoyingly cut off like Commissioner Gordon's.
Lizard- I really can't see him being brick built, he's not that big. Maybe I'll be wrong. My guess is that he'll be like the Outriders, no leg print or special head mold, just a new torso and face print.
Rhino- if he's a man in a mech suit, hopefully we'll get a new face print with his stupid forehead tattoos. Maybe a new torso print?
Sandman- not even sure we'll get him as a figure. He'd probably just be the comic based figure anyway.
Other Spider-Men- new torso and head prints are a given. I'm unsure whether they'll have duel molded legs, or printed legs, or just plain. Again, maybe they'll have printed arms, maybe they won't. You never know what Lego is going to do with Spider-Man figures.