You'll spot a Lego 'Brick Bucket' in the scene where 2 kids are playing Super Mario Bros 3 on the NES!
Leela enters the Planet Express ship in a demolition derby for spaceships, and one of the competing ships is made out of Lego.
Tom Hanks is in FAO Schwartz (Toy Store) having a gun battle with a kid and he’s creeping around a showcase, and in it very visibly are a few sets of Lego.
Big Momma's House
Some LEGO bricks can be spotted in the toy box.
There is a telephone made of LEGO.
It's about an eight-year older who suddenly grows up, and his body looks like he's 40 (Renato Pozzetto). Still, he thinks like the child he is. After the old woman says "this money is not enough to buy this Lego", while crying he says "This morning I turned 8 and I can't have Lego..."
Will Ferrel the elf builds elaborate buildings of New York out of LEGO bricks.
In the boat chase scene, a couple of rats are getting married; the Bride’s bouquet is some yellow Lego Flowers. Link to Clip
You can spot some 80s Lego sets in a toy store, and Gremlins pop up in the toy store (build a huge gremlin out of Lego blocks, then merrily knock it over)
Honey I Shrunk the Kids
The children find and decide to sleep in one of Nick's blue Lego pieces. It looks like a partially buried 2x4. Link to Clip
How To Be
A Boy is seen playing with LEGO Bricks.
(The) Indian in the Cupboard
In the great Robin Williams film, there are a few Lego sets (6175 Crystal Explorer Sub, and 6339 Shuttle Launch Pad) on the floor at one point.
Jingle All The Way
LEGO Display in a mall.
They use a remote controlled Lego robot in a heist. If I remember correctly it was used to disable an alarm system or something like that, amongst other things it could climb a staircase.
Kickin' It Old Skool
The main character is seen playing with Lego in a bar while the confused waitress watches him.
Lego Action Fun
A Two-Pack of stop motion Lego released on Video in 1998.
Le Grand Bazard
Maid in Manhattan
The girl's son plays with Kopaka and a Bohrok--there's this extended 10 second period just him playing with it.
Mr. Magorium's Wonder Emporium
There are Creator sets like the Dino, the Ferris wheel in the store.
New Police Story
A Jackie Chan film, the climax fight scene takes place in a Lego store.
Prep and Landing
There is Lego on the floor of the boys room, as shown in the clip at about 32 seconds. Link to clip
Spy Kids 2
Bionicle is visible in the background of some scenes.
Three Men and a Little Lady
There is a scene in the Kitchen where they are all adding pieces to a massive castle MOC
Thunderbirds Are Go
The buildings when the Zero X crashes have a Lego frame with card on the outside to add detail. Link to Clip
There’s LEGO on the kid's floor near the beginning. Giant LEGO bricks also appear close to the end in the big battle with the incarnation of evil where they are used to make the wall. Link to Clip
Toy Story 3
The teaser trailer features Lego bricks.
Where The Wild Things Are
About ten minutes into the movie Max is looking at his LEGO Minifigs. One’s an octan shirt with shades and a couple others including a yellow classic spaceman!
The little boy Luke has a huge space monorail layout!
The Brittas Empire - Mr. Brittas Changes Trains
When Gordon Brittas is hypnotised, he goes down to reception and find's receptionist Carole’s son Ben and a friend playing with a Duplo train on a small oval. Carole thinks she's in trouble for letting the kid's play with the trains outside. Brittas asks for various different thick rulebooks, but then makes a tunnel with three of the books over the track and a platform with the other. Brittas then asks for more tracks and later in the episode, he has made a large and elaborate Duplo train track layout with a few trains.
Death Note (Japanese Anime) - Episode 33
One of the main characters used Lego Minifigs to symbolize protagonists in the various plots that went on in the show.
Eastenders - Episode Aired on 08/12/09
Bradley was seen building the "Galactic Enforcer" from Space Police III with his girlfriend's son. Link to Clip (from about 25 minutes)
The appearance of some 2001 Bionicle sets Tahu and Gali in Louis' room.
The Family Guy – Season 5, Episode 11
Peter: You got Legos? Aw, sweet! Lois only buys me Mega Bloks.
Lois: They're the same thing, Peter.
Peter: You know what, Lois? They are not the same thing. And the sooner you get that through your thick skull, the sooner we can get this marriage back on track.
First Shop of Coffee Prince – Episode Five
Han Gyul gives her a little toy Lego robot.
Eun Chan is shown the back room, which houses Han Gyul’s collection of Legos (he used to work with them in the States); he marvels at concept of playing with toys: “Here, I can do anything I want” They play with the Lego (in a cute moment, Han Gyul “corrects” Eun Chan for bringing a bulldozer toy into the mix, because it doesn’t fit the time period of his horse-mounted knight-era setup).
Eun Chan takes out the Lego toy Han Gyul gave her, and tells it, “Now I have to tell him. Right?” (Later) Eun Chan looks at her Lego toy while repeating Han Gyul’s words to herself
Home Improvement (unknown episode)
Tim built the first "Bait and Tackle Shop with a built in Women's Department" out of Lego.
King of the Hill (unknown episode)
Joseph asked Bobby "Hey dude want to go melt some Lego?"
The Lego Group 'Official Commercials'
Malcolm in the Middle – Season 2, Episode 9 - High School Play
Dewy and Hal build a private Utopia with Lego and Playmobil bricks, Lois crashes into it and destroys it.
Season 4, Episode 10
Dewey plays with Bionicle to make fun of his two older brothers.
NCIS - Season 5, Episode 12
McGee uses a LEGO model of a warehouse to show how the bad guys could sneak out with the radar system without being caught on the cameras. Also Gibbs can be seen playing with the LEGO-forklift.
Ned's Declassified School Survival Guide
The character "Cookie" has a BIONICLE Metruan arm piece on his glasses.
Max plays with LEGO in several different Episodes.
There were two sketches done with (and about) Lego: In the episode "Slaughterhouse on the Prairie" there is a commercial for a new LEGO line called "LEGO Babel", and in the episode "Easter Basket" the pharaoh minifig makes his subjects build a pyramid for him out of Lego, but when they run out of bricks and start using different colors and parts from other themes, they decide to bury the pharaoh alive and keep the pimped out pyramid for themselves!
The Pretender – Pilot Episode
The main character builds the Empire State building out of LEGO. That model then appears in the opening credits and a number of later episodes (both in the present and flashback).
The Sarah Connor Chronicles: Automatic for the People
John and Riley wake up that same morning. She then gives him a Lego robot that she made for him out of the child's toys on the floor. He's briefly freaked by the representation of his future, but accepts it.
Season 2 – Episode 6
A little girl can be seen playing with Lego twice, and in response, her mother creates a large tower MOC for her.
Season 2 – Episode 14
This guy is playing with Makuta and other bionicles, as he describes the ball-and-joint system. Link to Clip
The Simpsons – Season 11 Episode 7
The family goes to a mega-store called SHØP (a parody of IKEA) and all the food and forks are Lego. Homer makes an apple out of bacon bricks.
Season 12, Episode 15
The Simpson family visits Blockoland (a parody of Legoland), a theme park which is completely made of blocks. Lisa is ripped off when her Eiffel Tower kit has a missing Blocko piece. In response, Homer "sticks up for the little guy", and he gets Lisa the piece she needs.
Season 19 Episode 3
Couch Gag: The family room is built out of Lego. Using stop motion filming, the family is then assembled out of Lego, one by one. Homer's full head of hair is replaced by a Lego block which more justifies his baldness. Homer responds with, "D'oh!"
The Sooty Show
There are some Lego sets scattered around Sooty, Sweep's and Soo's bedroom.
South Park - Season 5, Episode 14
In Butters’ very own episode he can be seen playing with Lego. Link to Clip
Season 8 - Episode 5 "You got F'd in the A".
Butters can be seen to be playing with Lego.
Stargate SG-1 – Season 1 Episode (?)
There is the 6339 Shuttle Launch Pad in O'Neill's son's room
That 70’s Show – Season 5 Episode 19, Bring It On Home
Hyde: Told you to look where you were going.
Jackie: Well what idiot leaves a Lego set right in front of the door?
Eric: You knocked over my space command centre? I spent three hours building that.
War at Home – Season 1 Episode (?)
the dad tries to connect with his son (TRIES) and says "you still play with LEGO?"
after that he says "That's OK, LEGOs are cool..." and they played with knights and castles. (They were playing with Duplo)